Boston Medical Group

Treatment areas

Product outline

Production process

Cross-linking

Because there are many Hyaluronic acid based fillers on the market, one may ask: "What makes the Revanesse product line different?"

The answer lies in our unique formula and patented Thixotropic cross-linking technology, which allows
a highly viscous gel to be injected easily through a fine gauge needle without causing degradation to the modified Hyaluronic acid particles.

Prollenium's precisely crafted cross-linking process is designed to maximize the effectiveness of the cross-linked chains present in the gel. This leads to a gel, which derives maximum benefit in terms of mechanical properties and durability, with a minimum amount of BDDE.

The osmolality and pH of the gel is balanced to be compatible with the fluid in the skin, neither drawing in or releasing water. This minimizes problems of overfilling or the need for volume correction. The degree of cross-linking is also selected to provide a desirable level of durability in the skin.

Optimizing all these properties provides for a dermal filler with superior performance and patient satisfaction.

Other HA fillers have large amounts of dangling and ineffective internal links. These fillers require more BDDE and can lead to higher incidences of adverse reactions (such as swelling) and decreased durability in the skin.	Thixofic Technology requires less BDDE as dangling and ineffective links are minimized. This more effective cross-linking technology results in a safe, long lasting product.
Effective links Dangling (partially reacted) links Ineffective internal links